Are there cancer-causing gut bacteria? Is butyrate carcinogenic?
In the last few posts , I have focused on whether the main substance produced during a ketogenic diet, β -hydroxybutyrate, could cause heart damage. The results are not clear, because the described mechanism should actually cause longevity. So something appears that is completely normal in nature, namely that SIRT7, which in principle has a very positive effect, can have a negative effect in some situations. But that is normal. The amount determines whether a substance will be a medicine or a poison, right? The same probably applies to butyrate, a short-chain fatty acid with four carbons, produced by intestinal bacteria. It seems that it can also be dangerous, it can cause colon cancer via cellular aging, senescence . Genetic removal of the ability of bacteria to produce butyrate (Mutant strain) leads to a reduction in the size and number of colorectal tumors in a mouse model of cancer. I found a study called " Gut bacteria identified in colorectal cancer patients promote tumouri