How to eat less and not be hungry with the help of glucose!

I know it sounds strange, but not all sugars are the same. I’ll try to summarize my proposal for an easy way to lose weight without starving yourself or overexercising, using D-glucose (dextrose). To understand how this diet system works, check out my older posts on overeating. In the first one, I explain why rats overeat by up to 50% when their diet changes. In my last post, I discuss why sucrose (regular sugar) could—but no longer can—be used to boost metabolism and raise body temperature in the distant past.  

To put it briefly, based on my analysis of these studies, I’ve concluded that hunger is controlled (in a still-unknown way) by the liver—specifically, by liver glycogen levels. If liver glycogen is sufficiently high before bedtime, it means we’ve eaten enough during the day and don’t feel the need to eat more. But if it’s low, hunger forces us to eat something at night to replenish glycogen stores. The entire problem of obesity, then, lies in the broken link between food and liver glycogen. Some modern foods don’t produce enough glycogen, so the body perceives them as insufficiently nourishing and drives us to overeat.  

We also know that if we consume excess protein, the resulting amino acids are transported to the liver and converted into glycogen. Protein doesn’t cause overeating—on the contrary, it ensures a precise link between food and liver glycogen.  

This isn’t the case with carbohydrates. Their effect depends mainly on how quickly they reach the liver and the state of metabolism. If you already have metabolic issues, glycogen synthesis happens much more slowly. Fast carbs don’t get fully converted into glycogen and are instead processed into muscle glycogen and fat. But this fat isn’t counted as resting energy storage—it leads to overeating. To achieve the same glycogen replenishment with lower conversion efficiency, you simply have to eat more.  

Slow carbs, however, convert into glycogen far more efficiently because synthesizing enzymes have enough time to process them. It takes longer, but overeating doesn’t occur. In fact, they paradoxically create a feeling of fullness even if we’ve eaten fewer calories than our energy expenditure. And that’s what we need. This is the path to weight loss without hunger. This is how we tap into our own energy reserves—body fat. When we eat fewer calories than we burn, the missing energy is supplied by releasing and burning stored fat. The key is not to consume too much dietary fat, forcing the body to use its own reserves. It’s best to stick to animal fats or fruit-based fats (avocado, coconut, olives). Never use seed-extracted vegetable oils—they contain omega-6 polyunsaturated fats, which oxidize heavily in the body or during cooking into highly toxic compounds. There’s no way to prevent this. The only solution is to avoid them entirely.

Another important prerequisite is to prevent the activation of the enzyme KHK (ketohexokinase), the enzyme for processing fructose. This will allow us to maintain as much fat burning as possible.

Fast carbohydrates without fructose (+Glu) activate the polyol pathway and act exactly the same as fructose (+Fru) or sucrose in food.

And this is how fructose drinks work to stop burn fat (right). Properly administered glucose (left) reduces fat burning only very slightly.

So, what’s my proposed method?

First step, buy glucose (dextrose). The right kind of glucose is called dextrose. You’ll need about 50g per day, so it’s better to buy in bulk. You can use it as a sweetener in drinks or consume it directly as a powder—it dissolves on the tongue. I recommend small doses, no more than one teaspoon at a time. Spread intake throughout the day, roughly every 30 minutes to an hour.  Why? Studies show that if your metabolism isn’t functioning well, glycogen synthesis slows down. So, carbs must not be consumed in large amounts at once—they need to be spaced out to ensure full glycogen conversion.  

If glucose is absorbed too quickly, the enzyme KHK activates, triggering the same mechanisms as fructose metabolism. When this happens, your body won’t burn fat for about 3 hours until the enzymes deactivate. If you trigger this at breakfast, snacks, lunch, and dinner, you’re guaranteeing that all dietary fat gets stored—and none gets burned. If you don’t burn it overnight, it stays put.  

My advice: Skip breakfast and sip glucose-sweetened drinks slowly in the morning. The key is not exceeding the absorption rate limit. We want fat burning! For the same reason, eliminate fructose-containing foods: fruit, sweets, sugary foods, table sugar, etc. Don’t worry—glucose is sweet enough to curb cravings.  

Meals & Protein

Eat one main protein-rich meal per day. It must contain plenty of protein and only a small carb portion. Avoid foods fried in overheated oil. Keep fat intake moderate—the less dietary fat you eat, the more your body burns its own stores (which is the goal!). You can add a second protein-based meal in the afternoon. Continue supplementing glucose in the afternoon. Portion control matters—you need a caloric deficit. This might sound restrictive, but it’s not. You can eat almost anything; you’re just controlling rate of intake and quantity (except protein—eat as much as you want!). This easily creates a daily deficit of 500–1000 kcal. If done right, you won’t feel hungry, even at maximum deficit. The result? Steady weight loss.  

How to dealing with senescent fat cells (p21)? These cells are few but disrupt overall function. To destroy them, I recommend pairing glucose with either:  

- Diluted vinegar (1 liter of 1% acetic acid solution spread throughout the day), or

- Sodium acetate (10g total, dosed at 1g per hour).  

This should activate/deactivate key enzymes via acetylation/deacetylation, driving the necessary changes. 

Theoretical Weight Loss Rate

If you cut ~33% of calories from fats, keep ~33% from protein with fat, and 33% from carbs, a 2400 kcal intake drops to 1600 kcal. Burning 800 kcal of fat ~100g of weight loss per day. Theoretically, that’s up to 3 kg (6.6 lbs) per month—without hunger or extreme exercise. Just normal activity.  

My (Short-Term) Experience

I’ve followed this for 5 weeks and lost 4 kg (8.8 lbs) without issues. Let’s see how it goes!  

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References:

Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice

Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus.

Ketohexokinase-C regulates global protein acetylation to decrease carnitine palmitoyltransferase 1a-mediated fatty acid oxidation

Consumption of fructose-sweetened beverages for 10 weeks reduces net fat oxidation and energy expenditure in overweight/obese men and women