MCT for Health

Whenever I add hypoxia to a search engine request for some metabolic connections, the search engine always comes up with something interesting.  As an example, this is the result of a search for a link between oxygen deficiency and sugar and fructose metabolism. Sugar or sucrose, a disaccharide composed of glucose and fructose, has interesting effects on the lifespan of cells lining the digestive system. I have discussed fructose and its effects here and here . Today, we'll look at an interesting study in mice that shows how fructose affects cell survival in relative oxygen deprivation, i.e. hypoxia. But presumably this is also true elsewhere in the body during pseudo-hypoxia caused by, for example, the auto-oxidation aldehyde products of polyunsaturated fats, i.e. MDA, 4-HNE or 9-ONA. We'll see that fructose is definitely involved as well. This also applies to high-fructose corn syrup (HFCS). This should have essentially the same properties as sugar, but there is information

Hydrogen peroxide H2O2 increases phosphorylation (activation) and slows down dephosphorylation (deactivation) of the insulin receptor, thereby increases its sensitivity to insulin and reduces insulin resistance. Don't you believe it? But not only that, it also keeps the suppression of insulin receptor sensitivity working after it has encountered high insulin levels, so it may also maintain insulin resistance.  Let's take a closer look at this. We can't do it without the details from the scientific studies, but no worries. I'll try to make this idea of mine, which I think is heretical for now, understandable. In fact, I wrote a very similar explanation two years ago , only it lacked the adaptive mechanism of insulin receptors, which was unknown at the time.  Schematic of a negative feedback insulin receptor that functions as a signal compressor. L et's start  by first explaining what insulin is. It is a substance that allows the storage of energy reserves. When you e