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Showing posts from April, 2026

Is it a good idea to suppress glucose production in the liver?

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Overweight and obesity are fairly common nowadays, much more common than they were, say, fifty or a hundred years ago. There are many opinions on the causes, but to me it currently appears to be the result of poisoning from food, drink, or the environment—whether the air we breathe or contamination by foreign electromagnetic signals. I assume that the environment and food simply play a role. Let’s review the most important processes that influence fat storage and obesity. First of all, rapid and easy storage into adipose tissue does not cause a problem and quickly removes fats from the blood. To achieve this, it is necessary to maintain metabolically healthy adipose tissue protected by the glutathione antioxidant system. How much fat will be stored is determined by excess—some fat is constantly being burned, and excess is stored. So it is determined by the ratio at which fats and glucose are burned. With any change in the ratio of fats and carbohydrates in the diet, suppression of fat...

Is the reduction of cholesterol by vegetable oils actually caused by their peroxidation?

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By chance, I looked at an older study from 2004 , which shows that oxidative stress affects the export of fats from the liver in the form of VLDL particles. Imagine that each lipoprotein particle VLDL/LDL contains exactly one molecule of the ApoB100 protein, so they are absolutely essential for the export of fats from the liver. So we already have three essential products needed for successful fat export from the liver, i.e. oleic acid, H2O2 , and ApoB100. We obtain oleic acid from food or from saturated fats through the slow process of DNL. With a relatively low-fat diet, this is not a problem. Saturated fats, when in excess, also produce enough H2O2 to activate the enzymes synthesizing VLDL. What about ApoB100? It is also easily produced. But the study tells us that there is a system that controls the quality of exported fats in VLDL particles. If peroxidized polyunsaturated fats are present, the enzymatic system PERPP degrades ApoB100 molecules and no VLDL particles can be exported,...