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Showing posts from January, 2024

Is increased cholesterol production a rescue mechanism for electron export?

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A provocative study was recently published showing that elevated cholesterol is better managed by twelve Oreo cookies a day than by traditional statin treatment. Of course, only in a special situation, but that's how it is. That situation is a very low-carbohydrate diet combined with low body fat. This led me to think that increased cholesterol is probably a way to solve some metabolic problem, specifically a lack of intermediate products of the TCA cycle. These are necessary for the export of energetic electrons through membranes, i.e. for the transfer of beta oxidation products (NADH) from peroxisomes to the cytosol and further to the mitochondria. In the case of a low-carbohydrate keto diet, electrons obtained by beta oxidation of fats in perixosomes can't be exported via the normal pathway via lactate or malate, but cholesterol synthesis  as rescue mechanism can be used.  And I even found a study that pretty much confirms it . Cholesterol synthesis is a relatively complex

Is photobiomodulation better with red, green, blue or white light?

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We have already seen the healing power of red light . Let's review what it can do. According to the latest research, red light passes through the skin into the tissues, even through the bones. It acts through nitric oxide (NO), probably by producing NO from nitrites by the enzyme CcO, which limits oxidation on the fourth mitochondrial complex CcO. This leads to a better distribution of oxygen throughout the tissue, resting oxidation improves, i.e. obtaining energy from food in the most efficient way through oxidative phosphorylation. But it's not a cure-all. This is because oxidation will not increase under load. Nitric oxide conserves oxygen and promotes the fermentation of glucose to lactate. Thus, energy in the form of ATP molecules is increased, but their origin is largely from glycolysis, not from oxidative phosphorylation. Let's try to find an even better solution, for example, we can look at what other colors of light or combinations of several colors do. Different w