MCT for Health

I found a very interesting study linking the activity of deacetylase SIRT1 to cellular senescence in fat cells. It beautifully connects the effect of acetic acid/acetate in suppressing fat cell senescence and promoting healthy fat storage. Increasingly, we see that phenomena we consider negative are actually highly adaptive responses to specific conditions and are, in fact, beneficial. I’ve previously demonstrated this with insulin resistance . The same applies to weight gain — efficient fat storage is advantageous and does not cause obesity. On the contrary, impaired fat storage leads to weight gain. This results in permanent insulin resistance caused by senescent cells. Surprising, isn’t it? SIRT1 deacetylase protects against cellular senescence in differentiated cells during the differentiation phase. If we accept that occasionally storing energy reserves for periods of scarcity is beneficial, then safely depositing excess available calories into adipose tissue is a vital adaptatio...