MCT for Health

I’ve discussed the inner lining of blood vessels — the endothelium — several times before. Virtually all studies conclude that oxidative stress causes metabolic and functional changes in these critically important cells that protect your vasculature. We already know that turbulent blood flow in vessel branches and bends triggers oxidative stress . That stress can also cause cellular senescence and reduce adaptability to changing conditions. This impairs oxygen and nutrient delivery and blocks angiogenesis — the formation of new blood vessels. Vasodilation — the ability of vessels to expand based on tissue needs — also stops working. Maintaining functional vascular endothelium is therefore vital. Let’s look at a study that examined endothelial cells in two states: a seemingly quiescent one where cells are just working, and a proliferative one where new blood vessels form. The quiescent state is different from cellular senescence, though they may appear similar. Quiescent endothelial ce...

I found a very interesting study linking the activity of deacetylase SIRT1 to cellular senescence in fat cells. It beautifully connects the effect of acetic acid/acetate in suppressing fat cell senescence and promoting healthy fat storage . Increasingly, we see that phenomena we consider negative are actually highly adaptive responses to specific conditions and are, in fact, beneficial. I’ve previously demonstrated this with insulin resistance . The same applies to weight gain — efficient fat storage is advantageous and does not cause obesity . On the contrary, impaired fat storage leads to weight gain. This results in permanent insulin resistance caused by senescent cells. Surprising, isn’t it? SIRT1 deacetylase protects against cellular senescence in differentiated cells during the differentiation phase. If we accept that occasionally storing energy reserves for periods of scarcity is beneficial, then safely depositing excess available calories into adipose tissue is a vital adaptat...