MCT for Health

Insulin resistance is only an emergency. Imagine that you are driving a car and you step on the gas (insulin). You expect an increase in engine speed, acceleration, but nothing. A red light on the dashboard lights up and the car goes into emergency mode (activates HIF-1α). Why IR 2.0? Because this post is a loose follow-up to the post on insulin resistance , which quite knowingly and controversially states that we lack hydrogen peroxide. Well, it is not quite true, rather  we lack oxygen in the tissues, CO2 ,  nitrites ,  ground-level ozone  or  light , but it is correct to state that hydrogen peroxide works against insulin resistance. The controversial part is that you'll hear everywhere how ROS, free radicals, cause insulin resistance, and I say that hydrogen peroxide lets glucose into the cells. I am not alone. Recently, in a similar vein, the well-known blogger Petro Dobromylskyj published a series of articles entitled Insulin mimesis . There he shows how v...

I first wrote about hydrogen peroxide (H2O2) two years ago. It was related to its regulatory and signaling functions. Its function as part of the tissue oxygenation regulatory loop I have described here is absolutely essential. Only few people realize, that the distribution of oxygen is controlled by the production of CO2, the transfer of oxygen from red blood cells to tissues is not a matter of course, it is a controlled process. Nitric oxide seems to be a backup system in case the basic regulation by CO2 and H2O2 does not work enough for some reason, when the cells cannot increase their activity at the request of the system. A typical example is the demand mediated by insulin, when we talk about insulin resistance, but it is actually a failure to transmit information from H2O2 to increase CO2 production and increase O2 delivery and to dilate blood vessels. H2O2 is not processed and therefore conveys another information, namely that the activity cannot be increased any more due to ...