Deactivation of the ARNT/HIF1β signal can prevent diabetes (T2DM) in mice
Since the very first post, I have tried to find the reason why the percentage of type 2 diabetics is constantly increasing in today's society. One of these analyzed scientific studies with the aim of finding the etiology of this disease , i.e. the real cause. If I had to summarize it briefly, at first, the fat cells are reprogrammed to release more free long-chain fatty acids (FFA) into the circulation, thus overloading the other organs with excess fuel. Lack of short and medium fatty acids will slow down metabolism and reduce fat burning. This causes a further increase in fatty acids. This increased level of FFA activates higher insulin secretion, but only initially. As demands for high insulin production increase, insulin resistance worsens, insulin production begins to gradually decrease, and glucose levels increase. This starts to damage other organs. The question is, are the beta cells of the pancreas damaged or are they just reacting to the metabolic state with a defense mech