Can vinegar/acetate counteract the negative effects of sugar consumption?
In several older posts, I have shown that about 5% sodium acetate in the diet of laboratory mice or rats can suppress or even correct metabolic changes caused by a high-fat diet . Could vinegar/acetate also counteract the negative changes in metabolism caused by fructose, i.e. sugar? Given that the essence of both metabolic changes is identical, namely the initiation of de novo lipogenesis (DNL), i.e. the activation of the ACC1 enzyme and the reversal of the direction of mitochondrial isocitrate dehydrogenase, accompanied by the production of ammonia and urea and the slowing down of metabolism . So it can be assumed that vinegar/acetate will also work against fructose. First, let's review what we already know about what fructose causes. The results of studies are not always unequivocally negative. Fructose alone manifests itself differently than when combined with glucose, such as in regular sugar. Fructose, specifically fructose-1-phosphate (F1P), affects glycolysis without being