MCT for Health

I have mentioned the positive effects of acetic acid and sodium acetate on metabolism many times here . Studies show that if the negative consequences of a high-fat diet are caused by fructose, i.e., the fructose contained in sucrose or produced in the liver from glucose (practically always), then sodium acetate often manages to reverse this effect in rodents, resulting in positive effects such as fat burning and weight loss. Mice, therefore, lose weight, normalize blood sugar and insulin levels, etc. We have also shown that the negative effects of fructose in combination with fats are caused by acetylation , specifically by the suppression of deacetylation by the enzyme SIRT2. This, among other things, causes the loss of CPT1 carnitine transporter molecules for the transport of long-chain fatty acids into mitochondria, so the fats must be stored. Fructose activates the enzyme KHK-C, and its increased presence (KHK-C OE) suppresses the enzyme deacetylase SIRT2. Thus, fructose prevents ...

I have a free continuation of my thoughts on how food intake is controlled in animals, and I assume that the same mechanism will work similarly in humans. If you haven't read it yet, I recommend it here and here . I have a feeling that we have not yet fully exploited the possibilities offered by the use of glucose as a dietary supplement. This is probably because it is glucose that increases insulin in the blood, and therefore, it is the main culprit that we must avoid. Really? Well, that is, of course, true if we undergo, for example, an oral glucose tolerance test ( OGTT ). Then yes, the culprit will be fully manifested here. But that is not what I mean. We already know that the main negative factor is the rate of intake. We know this from Dr. Richard Johnson and others. It is enough to finely grind or dissolve carbohydrates and mice will start to gain weight on their standard diet, just as they do on a human high-fat diet . So the speed of flooding the liver is decisive. How n...