MCT for Health

I know it sounds strange, but not all sugars are the same. I’ll try to summarize my proposal for an easy way to lose weight without starving yourself or overexercising, using D-glucose (dextrose).  To understand how this diet system works, check out my older posts on overeating. In the first one, I explain why rats overeat by up to 50% when their diet changes . In my last post, I discuss why sucrose (regular sugar) could—but no longer can—be used to boost metabolism and raise body temperature in the distant past .   To put it briefly, based on my analysis of these studies, I’ve concluded that hunger is controlled (in a still-unknown way) by the liver—specifically, by liver glycogen levels. If liver glycogen is sufficiently high before bedtime, it means we’ve eaten enough during the day and don’t feel the need to eat more. But if it’s low, hunger forces us to eat something at night to replenish glycogen stores. The entire problem of obesity, then, lies in the broken link ...

I enjoy controversial topics, and fructose is unique in this regard. Some experts completely condemn it, but as I’ve mentioned before , we have consumed fructose in fruit throughout our existence. To my knowledge, it has never been an issue until the last century. What are we doing wrong?    I’ll let you guess — what do you think? You see results from a study involving three low-fat diets (13% fat): mice on standard chow feed, starch-enriched feed, and sugar/sucrose-enriched feed (39%). For now, guess which curve corresponds to which diet. . I will attempt here to formulate a way to avoid overeating based on presumed mechanisms. The way we eat, especially the rate of food intake, is crucial. We must not overload the biological systems available to us. Every overload causes lasting changes.  First method:  Higher protein intake improves satiety signaling because excess amino acids are converted to liver glycogen via gluconeogenesis, which precisely signals when...

I have mentioned the positive effects of acetic acid and sodium acetate on metabolism many times here . Studies show that if the negative consequences of a high-fat diet are caused by fructose, i.e., the fructose contained in sucrose or produced in the liver from glucose (practically always), then sodium acetate often manages to reverse this effect in rodents, resulting in positive effects such as fat burning and weight loss. Mice, therefore, lose weight, normalize blood sugar and insulin levels, etc. We have also shown that the negative effects of fructose in combination with fats are caused by acetylation , specifically by the suppression of deacetylation by the enzyme SIRT2. This, among other things, causes the loss of CPT1 carnitine transporter molecules for the transport of long-chain fatty acids into mitochondria, so the fats must be stored. Fructose activates the enzyme KHK-C, and its increased presence (KHK-C OE) suppresses the enzyme deacetylase SIRT2. Thus, fructose prevents ...

I have a free continuation of my thoughts on how food intake is controlled in animals, and I assume that the same mechanism will work similarly in humans. If you haven't read it yet, I recommend it here and here . I have a feeling that we have not yet fully exploited the possibilities offered by the use of glucose as a dietary supplement. This is probably because it is glucose that increases insulin in the blood, and therefore, it is the main culprit that we must avoid. Really? Well, that is, of course, true if we undergo, for example, an oral glucose tolerance test ( OGTT ). Then yes, the culprit will be fully manifested here. But that is not what I mean. We already know that the main negative factor is the rate of intake. We know this from Dr. Richard Johnson and others. It is enough to finely grind or dissolve carbohydrates and mice will start to gain weight on their standard diet, just as they do on a human high-fat diet . So the speed of flooding the liver is decisive. How n...