Lactate shuts down glucose oxidation via magnesium ions.
I have discussed here many times that I consider suppressed energy metabolism of cells to be the main problem related to diseases of civilization. They simply for whatever reason, and there may be many of them, operate in energy-saving mode and conserve whatever they can. So they gradually suppress the consumption of saturated fats and glucose and store them as fat. There are then only few options left to awaken the energy mechanisms and increase the metabolic rate. If we use unsaturated fats to turn on peroxisomes , the entry of saturated fats into the mitochondria will be limited (via malonyl-CoA), carbohydrate burning in the mitochondria will also be limited (via phosphorylation of the PDH complex). Thus, for fuel processing, we are left with only peroxisomes processing unsaturated fats into acetate, and dicarboxylic acids, which ultimately produce succinate. In doing so, pyruvate will be converted to lactate in the peroxisomes . But glucose will compete in this, it will not be oxi