Is increased cholesterol production a rescue mechanism for electron export?
A provocative study was recently published showing that elevated cholesterol is better managed by twelve Oreo cookies a day than by traditional statin treatment. Of course, only in a special situation, but that's how it is. That situation is a very low-carbohydrate diet combined with low body fat. This led me to think that increased cholesterol is probably a way to solve some metabolic problem, specifically a lack of intermediate products of the TCA cycle. These are necessary for the export of energetic electrons through membranes, i.e. for the transfer of beta oxidation products (NADH) from peroxisomes to the cytosol and further to the mitochondria. In the case of a low-carbohydrate keto diet, electrons obtained by beta oxidation of fats in perixosomes can't be exported via the normal pathway via lactate or malate, but cholesterol synthesis as rescue mechanism can be used. And I even found a study that pretty much confirms it . Cholesterol synthesis is a relatively complex...