MCT for Health

I will try to summarize the latest findings as I have come to them from published studies, which strongly support my original idea that metabolic problems occur when a certain number of cells switch from oxidative to fermentative metabolism in tissues or cells that do not normally do this . These can be fat cells or liver cells, or supporting cells of the nervous system, but also cells of the bone marrow, the immune system, etc. A very wide range. In this blog, I have so far called this phenomenon pseudo-hypoxia, i.e. a state where a cell activates the same mechanisms as in a lack of oxygen, but in a situation where there is enough oxygen, in so-called normoxia. This condition also manifests itself as chronic inflammation, so many researchers consider inflammation to be the cause, without knowing what the specific cause is. From now on, I will call this state senescence . Why? Because senescence is the official term for a cell in a state where it has stopped its development, waiting a...

In the last few posts , I have focused on whether the main substance produced during a ketogenic diet,  β -hydroxybutyrate, could cause heart damage. The results are not clear, because the described mechanism should actually cause longevity. So something appears that is completely normal in nature, namely that SIRT7, which in principle has a very positive effect, can have a negative effect in some situations. But that is normal. The amount determines whether a substance will be a medicine or a poison, right? The same probably applies to butyrate, a short-chain fatty acid with four carbons, produced by intestinal bacteria. It seems that it can also be dangerous, it can cause colon cancer via cellular aging, senescence . Genetic removal of the ability of bacteria to produce butyrate (Mutant strain) leads to a reduction in the size and number of colorectal tumors in a mouse model of cancer. I found a study called " Gut bacteria identified in colorectal cancer patients promote tumouri...

I am following up on a previous post in which a study indicating the possibility of heart damage with a ketogenic diet was mentioned. The result of the search for the cause was the finding that the ketogenic diet reduces the activity of histone deacetylase 2 (HDAC2), which controls the deacetylase SIRT7. So SIRT7 is activated, which is supposed to be the problem. I did some googling and found that SIRT7 activation seems to be generally very good.  For example, it suppresses (pseudo)hypoxia, i.e. chronic inflammation .  I found a number of studies that consider the activation of SIRT7 to be very beneficial, they are looking for different drugs that would activate SIRT7, but they do not tell us that it is β-hydroxybutyrate or even the short-chain fatty acids acetate/vinegar and butyrate that activate SIRT7 through HDAC2 suppression. All these substances are considered very beneficial. So we have a rather fundamental contradiction here. Does SIRT7 activation have positive or ne...