SIRT7 - villain or key to longevity?
I am following up on a previous post in which a study indicating the possibility of heart damage with a ketogenic diet was mentioned. The result of the search for the cause was the finding that the ketogenic diet reduces the activity of histone deacetylase 2 (HDAC2), which controls the deacetylase SIRT7. So SIRT7 is activated, which is supposed to be the problem. I did some googling and found that SIRT7 activation seems to be generally very good. For example, it suppresses (pseudo)hypoxia, i.e. chronic inflammation . I found a number of studies that consider the activation of SIRT7 to be very beneficial, they are looking for different drugs that would activate SIRT7, but they do not tell us that it is β-hydroxybutyrate or even the short-chain fatty acids acetate/vinegar and butyrate that activate SIRT7 through HDAC2 suppression. All these substances are considered very beneficial. So we have a rather fundamental contradiction here. Does SIRT7 activation have positive or negative ef