MCT for Health

A deficiency of amino acids (proteins) in the cell activates the enzyme SIRT2 . Activation of the enzyme KHK-C, i.e. the mere presence of fructose, which needs this enzyme for its activation, turns off the enzyme SIRT2 . Therefore, fructose controls the acetylation of many enzymes and reprograms metabolism. After reading many studies on fructose, I must conclude that sugar could really be behind the epidemic of obesity, diabetes, high blood pressure, etc., although I still think that the long-term effects of fructose are linked to the consumption of plant polyunsaturated oils, their peroxidation into aldehydes, and the initiation of cellular senescence . This is especially supported by the increase in their consumption in the 20th and 21st centuries. We have been consuming fructose in fruit and honey since time immemorial. SIRT2, as an indicator of the deficiency of amino acids, deacetylates ACSS2 and suppresses the formation of new fat droplets. Diabetics have their artificial sweeten...

I'm following up on the previous post, read it if you haven't already. I have to go back to fructose and its interaction with fat burning. If we want to come to any substantiated statement about the harmfulness of fructose and oils, it won't be easy. Both have their clearly negative but also positive effects, as I already wrote, it depends on the situation and criteria. But when it comes to long-chain polyunsaturated fatty acids, I can't help  I feel that they come in second place. At the beginning of the metabolic degradation process, fructose, probably in combination with any long-chain fat, is the culprit. We can even trigger the same negative service by combining glucose with any long-chain fat because flooding the liver with glucose can trigger the production of fructose from glucose, the so-called polyol pathway . So even if you avoid fructose and regular sugar, any fast carbohydrates can trigger the production of fructose. This is probably related to the need to...

And again, fructose! Sugar! White poison! Well, wait, maybe it depends on the situation. Let's look at an interesting study that examined the effects of fructose on the metabolism of mice. Animal models have the advantage that you have everything under control, so you can easily observe the mechanisms of how things happen. We already know about fructose , it activates the processes of glycolysis of glucose to lactate to obtain energy without the need for oxygen . This is not always bad, sometimes it can be useful, sometimes not. With simple reasoning, we can directly deduce that fructose does not promote the oxidation of fats to ATP energy, because only glucose or some amino acids can be fermented. On the contrary, when there is an excess of glucose, fermentation to lactate can be useful because it relieves the mitochondria and helps reduce the level of glucose in the blood. I mentioned the mechanism of increased lactate production in another post, see for yourself . What is intere...