MCT for Health

The literature usually states that blue light is harmful because it damages DNA. This damaged DNA activates the mechanism of cellular senescence or directly triggers cell removal through apoptosis/ferroptosis. Something about this doesn't add up to me.  DNA damage occurs constantly in our bodies, and at the same time, DNA is constantly being repaired . Why should blue light in particular be so extremely harmful, much more so than other destructive environmental factors, such as cosmic radiation? It doesn't make much sense to me. Don't you think? First of all, if blue and UV-A light directly damage DNA, how is it possible that there are methods that protect cells? Yes, you might argue that activating pigment production can protect cells by safely absorbing blue radiation. But pigment production is only triggered by UV-B. So how is it that there are methods to protect cells from blue light even in the absence of UV-B? Perhaps I'm being too bold, but I believe that DNA dam...

If you haven't read the previous post on this topic, here it is: Can Mobile Phone and Computer Screens Cause Obesity? What Is the Difference Between Blue Light and a High-Fat Diet? I have to return once again to the issue of modern light sources and the filtering of daylight by windows and glasses. It seems that inadequate research before the widespread adoption of new LED light sources may be responsible for a number of health problems. We could already observe changes when fluorescent computer screens were introduced, when it became apparent that their light could cause vision problems. Our ancestors were fairly lucky when fluorescent tubes were introduced into schools and workplaces. Fluorescent lights were developed in such a way that they are still used today as control sources of white light in animal studies . That does not mean they have no effect; it only means that the effect was sufficiently small that it went unnoticed. LED light sources are different. I really like thi...

We already know that in order to maintain a healthy metabolism, we need to keep our mitochondria in very good condition. But how do we do that? When I tried to find out what the usual composition of cardiolipin, one of the most important phospholipids in a healthy mitochondrial membrane, is, I always found that it contains a high percentage of tetralinoleoyl cardiolipin (4L-CL), i.e. cardiolipin containing four linoleic acid chains. Cis-vaccenic acid (cVA) comes in second, and only further down do we find, for example, DHA (in mitochondria from the heart), oleic acid, or other polyunsaturated fatty acids. In some studies, researchers have tried to replace linoleic acid with the long-chain fatty acids ARA and DHA, but the results are not particularly encouraging. For example, in this study , they tried to remodel cardiolipin by manipulating the enzyme ALCAT1 and achieved the incorporation of more DHA into cardiolipin, but they obtained the best results after shutting down remodeling v...