MCT for Health

In my previous post , I pointed out a study in which scientists extended the lifespan of mice by up to five months, about 17%, through mechanical stress induced by ultrasound. I also mentioned that it would be beneficial to combine the therapy with the supplementation of sodium acetate or vinegar, as these activate the same pathways, namely SIRT1 and AMPK . Immediately afterward, I came across a study showing the successful suppression of cellular senescence using sodium acetate in vascular endothelial cell cultures — the inner lining of blood vessels. Almost as if on cue, the study was published just a few days ago, on May 12th of this year. This is a fascinating study that combines the investigation of substances produced by gut bacteria that damage our blood vessels and accelerate the aging of the inner vascular lining. Researchers identified the compounds phenylacetic acid (PAA) and phenylacetylglutamine (PAGln), which are primarily produced by bacteria of the genus Clostridium. T...

In my previous post , I discussed aging and how it can be influenced. We saw that aging is closely linked to the aging of individual cells, with their undamaged DNA, and the activity of repair mechanisms. To ensure proper DNA repair, the cellular energy production system — specifically, ATP synthesis — must function correctly. This requires a well-working antioxidant system based on glutathione, which must not be disrupted by products of auto-oxidation of omega-6 linoleic acid. These oxylipins (e.g., HNE) bind to enzymes and impair their function. If they block DNA repair, they trigger cellular senescence. As we age, senescent cells accumulate . This is the body’s defense mechanism — cells reduce energy production via oxidative phosphorylation and switch to fermentation, keeping auto-oxidation within tolerable limits. While senescent cells remain partially functional, they cannot replicate when needed, nor can they be cleared when in excess. They also ignore external signals. Is it pos...