Do Omega-3s Really Act Against Omega-6s, or Is It the Effect of Acetate Against Fructose?
I’ll loosely follow up on an earlier post, where I examined the properties of fructose and acetate and how they act against each other . That post mainly dealt with enzyme acetylation — that is, the change of their “decoration” by an acetyl group. Fructose suppresses the deacetylase SIRT2 and probably also SIRT1. Acetate, on the other hand, activates SIRT1 and possibly SIRT2. Both substances thus act as regulators of the same processes, but in opposite directions. They therefore ensure balance. That’s important, because if there is an excess of one substance, its effect can be compensated by the other; we’re not left without a means of compensation — and that’s crucial. Today I’d like to connect this model with the vicious cycle of obesity , as I described in previous posts. Few people realize that the effect of polyunsaturated oils on metabolism is, in fact, the effect of fructose produced via the polyol pathway in the liver through the presence of aldehydes such as 4-HNE. This is how...